Updated: April the 11th 2021, to include links to our Permissions Reset application and Howard Oakley's article. Further update to include note about comparing entitlements and provision profiles.
Several people have contacted me since the release of macOS Big Sur, in that their customers are getting this error.
In some cases, Apple even displays a dialog about how the application is malware.
Howard Oakley has also written about this issue when you dont have permission to run an app on an m1 mac/
If you use App Wrapper to wrap your applications, download the latest release from ohanaware.com/appwrapper/
You can try using Permissions Reset from ohanaware.com/permissionsreset/
Also check and make sure that your application entitlements match those from the provision profile.