Hardened Runtime

If the application no longer launches once "Hardened Runtime" has been enabled in the Sidebar, there are a number of options in the "Capabilities" Page of the App Wrapper document window.

Using Xojo Script or another "Scripting" library.

First select "Allow Execution of JIT-Compiled code" and try again. If the application still doesn't work, also enable "Allow Unsigned Executable Memory".

App uses 3rd Party libraries

Select "Disable Library Validation" and try again.

Electron Apps

Please see this page on Electron Apps and App Wrapper.